研究发现花生过敏的新基因风险因子
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By LabMedica International staff writers Posted on 06 Dec 2017 |
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图片：全基因组基因分型是发现致病变异的一件重要工具（图片蒙Megan Smolenyak惠赐）。
人幼年时会得花生过敏，长大后很少自愈。大约1%的加拿大成人和2%-3%的加拿大儿童会得花生过敏，症状可能很严重甚至致命。
研究发现了与花生过敏相关的一个新基因，进一步证明基因对于食物过敏的形成有一定作用，为将来的研究、更好的诊断产品和新治疗方案开辟了道路。
一个由多国科学家组成的科研小组与加拿大温哥华市不列颠哥伦比亚大学的科学家合作，通过全基因组关联研究(GWAS)扫描了850名花生过敏者及近1,000名无花生过敏者的DNA里超过750万个基因位点，寻找可能与食物过敏有关的标记物。他们征调了“加拿大花生过敏登记表”里的花生过敏参与者。科研小组还重新分析了北美、澳大利亚、德国和荷兰的另外六项基因研究汇总来的结果。在美国加利福尼亚州圣迭戈市Illumina公司的Omni 2.5M+Exome 8v1.1芯片上对1,974名受试者（987名病例，987名对照）进行基因分型。
科学家报告说，他们的研究第一次把EMSY, BRCA2交互转录阻遏因子(EMSY)基因座与食物过敏联系起来，这些发现表明基因不仅在食物过敏的形成过程中发挥重要作用，还在一般的过敏倾向形成过程中发挥重要作用。该基因名为c11orf30/EMSY (EMSY)，我们已知它在其它过敏相关的病症中起作用，如湿疹、哮喘和过敏性鼻炎。科研小组还发现了证据证明另五个基因位点也涉嫌。
该研究的论文发表于2017年10月10日的《过敏与临床免疫学杂志》(Journal of Allergy and Clinical Immunology)。资深作者、副教授Denise Daley博士说：“食物过敏是基因因子和环境因子共同作用的结果，但是关于基因机理的数据出奇地少。这一基因联系的发现让我们能更全面地描述食物过敏的起因，最终帮助医生发现有风险的儿童。”
Related Links:
不列颠哥伦比亚大学
Illumina
研究发现了与花生过敏相关的一个新基因，进一步证明基因对于食物过敏的形成有一定作用，为将来的研究、更好的诊断产品和新治疗方案开辟了道路。
一个由多国科学家组成的科研小组与加拿大温哥华市不列颠哥伦比亚大学的科学家合作，通过全基因组关联研究(GWAS)扫描了850名花生过敏者及近1,000名无花生过敏者的DNA里超过750万个基因位点，寻找可能与食物过敏有关的标记物。他们征调了“加拿大花生过敏登记表”里的花生过敏参与者。科研小组还重新分析了北美、澳大利亚、德国和荷兰的另外六项基因研究汇总来的结果。在美国加利福尼亚州圣迭戈市Illumina公司的Omni 2.5M+Exome 8v1.1芯片上对1,974名受试者（987名病例，987名对照）进行基因分型。
科学家报告说，他们的研究第一次把EMSY, BRCA2交互转录阻遏因子(EMSY)基因座与食物过敏联系起来，这些发现表明基因不仅在食物过敏的形成过程中发挥重要作用，还在一般的过敏倾向形成过程中发挥重要作用。该基因名为c11orf30/EMSY (EMSY)，我们已知它在其它过敏相关的病症中起作用，如湿疹、哮喘和过敏性鼻炎。科研小组还发现了证据证明另五个基因位点也涉嫌。
该研究的论文发表于2017年10月10日的《过敏与临床免疫学杂志》(Journal of Allergy and Clinical Immunology)。资深作者、副教授Denise Daley博士说：“食物过敏是基因因子和环境因子共同作用的结果，但是关于基因机理的数据出奇地少。这一基因联系的发现让我们能更全面地描述食物过敏的起因，最终帮助医生发现有风险的儿童。”
Related Links:
不列颠哥伦比亚大学
Illumina
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