基态人类干细胞促进再生医学和人类发展的研究
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By LabMedica International staff writers Posted on 03 Dec 2013 |
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发现了一种维持人类诱导多能干细胞（iPS 细胞）最早期、最原始、最基态的方法，预期该方法能促进这些干细胞在再生医学、患者特定 iPS 细胞疾病模型，以及在早期人类发展的体外和体内研究中的应用。
诱导多能干细胞形成的方法通常为：向诸如皮肤细胞的此类成人细胞基因组中插入 4 个基因，然后使用鸡尾酒式组合的生长因子培养改良的细胞。然后分化的细胞还原为胚胎干细胞类似状态，而不是成为多种不同细胞类型的成熟细胞。此问题的症结在于，缺乏将干细胞长期保持在未分化状态的方法。
Weizmann Institute of Science (Rehovot, Israel) 的研究人员使用小鼠和人类细胞进行研究，努力解决此问题。他们尤其感兴趣建立一种技术，将人类的 iPS 细胞保持在最早期基态，以模拟小鼠的干细胞行为，后者能更长时间自然的保持未分化状态。
研究人员在 2013 年 10 月 30 日的《自然杂志》(Nature) 网络版中报道，已成功确立了指定条件，以便于将已经成为始发态人类胚胎干细胞的细胞衍生为未经基因改良的人类基态多能干细胞、经由 iPS 细胞重新编程从体细胞衍生为未经基因改良的人类基态多能干细胞，或直接从囊胚泡衍生为未经基因改良的人类基态多能干细胞。新的基态多能细胞保留了与小鼠基态胚胎干细胞高度相似的分子特性和功能特性，并有别于普通的始发人类多能干细胞。
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Weizmann Institute of Science
诱导多能干细胞形成的方法通常为：向诸如皮肤细胞的此类成人细胞基因组中插入 4 个基因，然后使用鸡尾酒式组合的生长因子培养改良的细胞。然后分化的细胞还原为胚胎干细胞类似状态，而不是成为多种不同细胞类型的成熟细胞。此问题的症结在于，缺乏将干细胞长期保持在未分化状态的方法。
Weizmann Institute of Science (Rehovot, Israel) 的研究人员使用小鼠和人类细胞进行研究，努力解决此问题。他们尤其感兴趣建立一种技术，将人类的 iPS 细胞保持在最早期基态，以模拟小鼠的干细胞行为，后者能更长时间自然的保持未分化状态。
研究人员在 2013 年 10 月 30 日的《自然杂志》(Nature) 网络版中报道，已成功确立了指定条件，以便于将已经成为始发态人类胚胎干细胞的细胞衍生为未经基因改良的人类基态多能干细胞、经由 iPS 细胞重新编程从体细胞衍生为未经基因改良的人类基态多能干细胞，或直接从囊胚泡衍生为未经基因改良的人类基态多能干细胞。新的基态多能细胞保留了与小鼠基态胚胎干细胞高度相似的分子特性和功能特性，并有别于普通的始发人类多能干细胞。
Related Links:
Weizmann Institute of Science
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